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Review
. 2014 Jun 29;10(3):434-8.
doi: 10.5114/aoms.2014.43737. Epub 2014 Jun 27.

Interleukin-1B-31T/C promoter polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis

Min Xiao  1 , Lingli Guo  1 , Tao Wang  1 , Tao Zhu  1 , Liuqun Jia  1 , Lei Chen  1 , Funqiang Wen  1
Affiliations
Review

Interleukin-1B-31T/C promoter polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis

Min Xiao et al. Arch Med Sci. .

Abstract

Introduction: The role of interleukin (IL)-1β -31T/C promoter polymorphism in the pathogenesis of chronic obstructive pulmonary disease (COPD) has been studied with inconsistent results. This meta-analysis was performed to assess the association of IL-1β -31T/C promoter polymorphism with COPD susceptibility.

Material and methods: Published case-control studies from PubMed and China National Knowledge Infrastructure (CNKI) databases were retrieved. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.

Results: Six case-control studies were included in this meta-analysis. The pooled effect size showed that IL-1β -31T/C was significantly associated with COPD susceptibility in an overdominant genetic model (CC+TT vs. TC, OR: 0.77, 95% CI: 0.63-0.94), indicating that homozygotes (CC and TT) had a decreased risk for COPD compared with heterozygotes (TC). In the subgroup analysis by ethnicity, the results indicated that IL-1β -31T/C was significantly correlated with COPD susceptibility in Asians (overdominant model, OR: 0.75, 95% CI: 0.61-0.93), further suggesting a protective role of IL-1β -31T/C in COPD pathogenesis in Asians. Moreover, after excluding the study without Hardy-Weinberg equilibrium, the pooled results were robust and no publication bias was found in this study.

Conclusions: This meta-analysis suggests that IL-1β -31T/C promoter polymorphism confers protection against COPD in Asians.

Keywords: chronic obstructive pulmonary disease; interleukin-1β; polymorphism.

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Figures

Figure 1
Figure 1
Flow diagram of search process
Figure 2
Figure 2
Forest plots of OR with 95% CI for the association of IL-1β –31T/C and COPD risk (CC+TT vs. TC)
Figure 3
Figure 3
Forest plots of OR with 95% CI for the association of IL-1β –31T/C and COPD risk in Asians (CC+TT vs. TC)
Figure 4
Figure 4
Begg's funnel plot for evaluation of publication bias in the included studies on the associations of IL-1β –31T/C with COPD risk
See this image and copyright information in PMC

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