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Comment
. 2014 Aug 6;6(248):248fs31.
doi: 10.1126/scitranslmed.3009919.

Street-experienced peripheral B cells traffic to the brain

Daniel R Lu  1 , William H Robinson  2
Affiliations
Comment

Street-experienced peripheral B cells traffic to the brain

Daniel R Lu et al. Sci Transl Med. .

Abstract

Deep sequencing of immunoglobulin repertoires in multiple sclerosis patients reveals dysregulation of peripheral B cell immunity (Palanichamy et al. and Stern et al., this issue).

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Figures

Figure 1
Figure 1. Peripheral antigen experience modulates CNS B-cell responses in MS
Peripheral antigen exposure results in antigen priming of naive B cells and the formation of immunological memory. These B cells undergo affinity maturation, clonal expansion, and extravasation into the CNS. Formation of ectopic lymphoid-like structures in the CNS perpetuates the activation and affinity maturation of these B cells, which transmigrate between the CNS and periphery. B cells likely contribute to the pathogenesis of MS by producing autoantibodies, by serving as professional antigen-presenting cells, and/or by producing pro-inflammatory cytokines. SHM, somatic hypermutation.
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References

    1. Serafini B, Rosicarelli B, Magliozzi R, Stigliano E, Aloisi F. Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol. 2004;14:164–174. - PMC - PubMed
    1. Kuenz B, et al. Cerebrospinal fluid B cells correlate with early brain inflammation in multiple sclerosis. PloS one. 2008;3:e2559. - PMC - PubMed
    1. Krumbholz M, Derfuss T, Hohlfeld R, Meinl E. B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nat Rev Neurol. 2012;8:613–623. - PubMed
    1. Lehmann-Horn K, Kronsbein HC, Weber MS. Targeting B cells in the treatment of multiple sclerosis: recent advances and remaining challenges. Ther Adv Neurol Disord. 2013;6:161–173. - PMC - PubMed
    1. von Budingen HC, et al. B cell exchange across the blood-brain barrier in multiple sclerosis. J Clin Invest. 2012;122:4533–4543. - PMC - PubMed

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