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. 2014:2014:193516.
doi: 10.1155/2014/193516. Epub 2014 Jul 2.

Acinetobacter baumannii infection in prior ICU bed occupants is an independent risk factor for subsequent cases of ventilator-associated pneumonia

Eirini Tsakiridou  1 , Demosthenes Makris  1 , Zoe Daniil  2 , Efstratios Manoulakas  1 , Vasiliki Chatzipantazi  3 , Odysseas Vlachos  3 , Grigorios Xidopoulos  3 , Olympia Charalampidou  3 , Epaminondas Zakynthinos  1
Affiliations

Acinetobacter baumannii infection in prior ICU bed occupants is an independent risk factor for subsequent cases of ventilator-associated pneumonia

Eirini Tsakiridou et al. Biomed Res Int. 2014.

Abstract

Objective: We aimed to evaluate risk factors for ventilator-associated pneumonia (VAP) due to Acinetobacter baumannii (AbVAP) in critically ill patients.

Methods: This was a prospective observational study conducted in an intensive care unit (ICU) of a district hospital (6 beds). Consecutive patients were eligible for enrolment if they required mechanical ventilation for >48 hours and hospitalization for >72 hours. Clinical, microbiological, and laboratory parameters were assessed as risk factors for AbVAP by univariate and multivariate analysis.

Results: 193 patients were included in the study. Overall, VAP incidence was 23.8% and AbVAP, 11.4%. Previous hospitalization of another patient with Acinetobacter baumannii infection was the only independent risk factor for AbVAP (OR (95% CI) 12.016 (2.282-19.521) P < 0.001). ICU stay (25 ± 17 versus 12 ± 9 P < 0.001), the incidence of other infections (OR (95% CI) 9.485 (1.640-10.466) P = 0.002) (urinary tract infection, catheter related infection, and bacteremia), or sepsis (OR (95% CI) 10.400 (3.749-10.466) P < 0.001) were significantly increased in patients with AbVAP compared to patients without VAP; no difference was found with respect to ICU mortality.

Conclusion: ICU admission or the hospitalization of patients infected by Acinetobacter baumannii increases the risk of AbVAP by subsequent patients.

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Figures

Figure 1
Figure 1
Flow chart of the study.
Figure 2
Figure 2
Distribution of VAP cases per two-month period.
Figure 3
Figure 3
Occupancy of the ICU per two-month period.
See this image and copyright information in PMC

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