Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014:2014:413150.
doi: 10.1155/2014/413150. Epub 2014 Jul 3.

Nutritional risk factors for age-related macular degeneration

Lebriz Ersoy  1 , Tina Ristau  1 , Yara T Lechanteur  2 , Moritz Hahn  3 , Carel B Hoyng  2 , Bernd Kirchhof  1 , Anneke I den Hollander  2 , Sascha Fauser  1
Affiliations

Nutritional risk factors for age-related macular degeneration

Lebriz Ersoy et al. Biomed Res Int. 2014.

Erratum in

Abstract

Purpose: To evaluate the role of nutritional factors, serum lipids, and lipoproteins in late age-related macular degeneration (late AMD).

Methods: Intake of red meat, fruit, fish, vegetables, and alcohol, smoking status, and body mass index (BMI) were ascertained questionnaire-based in 1147 late AMD cases and 1773 controls from the European Genetic Database. Serum levels of lipids and lipoproteins were determined. The relationship between nutritional factors and late AMD was assessed using logistic regression. Based on multivariate analysis, area-under-the-curve (AUC) was calculated by receiver-operating-characteristics (ROC).

Results: In a multivariate analysis, besides age and smoking, obesity (odds ratio (OR): 1.44, P = 0.014) and red meat intake (daily: OR: 2.34, P = 8.22 × 10(-6); 2-6x/week: OR: 1.67, P = 7.98 × 10(-5)) were identified as risk factors for developing late AMD. Fruit intake showed a protective effect (daily: OR: 0.52, P = 0.005; 2-6x/week: OR: 0.58, P = 0.035). Serum lipid and lipoprotein levels showed no significant association with late AMD. ROC for nutritional factors, smoking, age, and BMI revealed an AUC of 0.781.

Conclusion: Red meat intake and obesity were independently associated with increased risk for late AMD, whereas fruit intake was protective. A better understanding of nutritional risk factors is necessary for the prevention of AMD.

PubMed Disclaimer

References

    1. Friedman DS, O'Colmain BJ, Muñoz B, et al. Prevalence of age-related macular degeneration in the United States. Archives of Ophthalmology. 2004;122(4):564–572. - PubMed
    1. Bressler NM, Doan QV, Varma R, et al. Estimated cases of legal blindness and visual impairment avoided using ranibizumab for choroidal neovascularization: non-Hispanic white population in the United States with age-related macular degeneration. Archives of Ophthalmology. 2011;129(6):709–717. - PubMed
    1. Chew EY, Lindblad AS, Clemons T. Summary results and recommendations from the age-related eye disease study. Archives of Ophthalmology. 2009;127(12):1678–1679. - PMC - PubMed
    1. Sin HPY, Liu DTL, Lam DSC. Lifestyle modification, nutritional and vitamins supplements for age-related macular degeneration. Acta Ophthalmologica. 2013;91(1):6–11. - PubMed
    1. Vishwanathan R, Chung M, Johnson EJ. A systematic review on zinc for the prevention and treatment of age-related macular degeneration. Investigative Ophthalmology and Visual Science. 2013;54(6):3985–3998. - PubMed

Publication types

LinkOut - more resources