MicroRNAs: novel players in cancer diagnosis and therapies
- PMID: 25101302
- PMCID: PMC4101974
- DOI: 10.1155/2014/959461
MicroRNAs: novel players in cancer diagnosis and therapies
Abstract
First discovered in 1993, microRNAs (miRNAs) have been one of the hottest research areas over the past two decades. Oftentimes, miRNAs levels are found to be dysregulated in cancer patients. The potential use of miRNAs in cancer therapies is an emerging and promising field, with research finding miRNAs to play a role in cancer initiation, tumor growth, and metastasis. Therefore, miRNAs could become an integral part from cancer diagnosis to treatment in future. This review aims to examine current novel research work on the potential roles of miRNAs in cancer therapies, while also discussing several current challenges and needed future research.
Similar articles
-
Current perspectives on the dysregulated microRNAs in gastric cancer.Mol Biol Rep. 2020 Sep;47(9):7253-7264. doi: 10.1007/s11033-020-05720-z. Epub 2020 Aug 9. Mol Biol Rep. 2020. PMID: 32776162 Review.
-
Cross-Roads to Drug Resistance and Metastasis in Breast Cancer: miRNAs Regulatory Function and Biomarker Capability.Adv Exp Med Biol. 2019;1152:335-364. doi: 10.1007/978-3-030-20301-6_18. Adv Exp Med Biol. 2019. PMID: 31456193 Review.
-
MicroRNAs and cancer; an overview.Curr Pharm Biotechnol. 2014;15(5):430-7. doi: 10.2174/1389201015666140519095304. Curr Pharm Biotechnol. 2014. PMID: 24846068 Review.
-
Molecular mechanisms and clinical implications of miRNAs in drug resistance of esophageal cancer.Expert Rev Gastroenterol Hepatol. 2017 Dec;11(12):1151-1163. doi: 10.1080/17474124.2017.1372189. Epub 2017 Aug 30. Expert Rev Gastroenterol Hepatol. 2017. PMID: 28838272 Review.
-
miRNA-based biomarkers, therapies, and resistance in Cancer.Int J Biol Sci. 2020 Jul 19;16(14):2628-2647. doi: 10.7150/ijbs.47203. eCollection 2020. Int J Biol Sci. 2020. PMID: 32792861 Free PMC article. Review.
Cited by
-
MicroRNA-142-5p promotes cell growth and migration in renal cell carcinoma by targeting BTG3.Am J Transl Res. 2017 May 15;9(5):2394-2402. eCollection 2017. Am J Transl Res. 2017. PMID: 28559989 Free PMC article.
-
MicroRNA-30a-3p functions as a tumor suppressor in renal cell carcinoma by targeting WNT2.Am J Transl Res. 2019 Aug 15;11(8):4976-4983. eCollection 2019. Am J Transl Res. 2019. PMID: 31497214 Free PMC article.
-
miR-486-5p inhibits cell proliferation and invasion through repressing GAB2 in non-small cell lung cancer.Oncol Lett. 2018 Sep;16(3):3525-3530. doi: 10.3892/ol.2018.9053. Epub 2018 Jun 29. Oncol Lett. 2018. PMID: 30127957 Free PMC article.
-
Exosomal microRNA Biomarkers: Emerging Frontiers in Colorectal and Other Human Cancers.Expert Rev Mol Diagn. 2016;16(5):553-67. doi: 10.1586/14737159.2016.1156535. Epub 2016 Mar 16. Expert Rev Mol Diagn. 2016. PMID: 26892862 Free PMC article. Review.
-
MicroRNA-18a-5p functions as an oncogene by directly targeting IRF2 in lung cancer.Cell Death Dis. 2017 May 4;8(5):e2764. doi: 10.1038/cddis.2017.145. Cell Death Dis. 2017. PMID: 28471447 Free PMC article.
References
-
- Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75(5):843–854. - PubMed
-
- Chen K, Rajewsky N. The evolution of gene regulation by transcription factors and microRNAs. Nature Reviews Genetics. 2007;8(2):93–103. - PubMed
-
- Fu X, Tian J, Zhang L, Chen Y, Hao Q. Involvement of microRNA-93, a new regulator of PTEN/Akt signaling pathway, in regulation of chemotherapeutic drug cisplatin chemosensitivity in ovarian cancer cells. FEBS Letters. 2012;586(9):1279–1286. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous