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. 2014 Jun-Jul;22(3):651-4.

Metabolic complications of HIV infection and its therapies

Edgar Turner Overton  1
Affiliations

Metabolic complications of HIV infection and its therapies

Edgar Turner Overton. Top Antivir Med. 2014 Jun-Jul.

Abstract

Non-AIDS morbidity and mortality are increasingly common in the HIV-infected population. Chronic inflammation and immunosenescence result in early onset of conditions associated with aging, including atherosclerosis and frailty. Risk for non-AIDS-related morbidity is also related to the metabolic effects of antiretroviral therapy and the increased prevalence of traditional cardiovascular and other risk factors in the HIV-infected population. Risk reduction is centered on maintaining full viral suppression and aggressively implementing measures to reduce standard modifiable risk factors. This article summarizes a presentation by Edgar Turner Overton, MD, at the IAS-USA continuing education program held in New York, New York, in October 2013.

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Conflict of interest statement

Financial affiliations in the past 12 months: Dr Overton has received research funding through the University of Alabama Birmingham School of Medicine from Gilead Sciences, Inc, AbbVie, Vertex Pharmaceuticals, Inc, and Bristol-Myers Squibb. He has served as a consultant to Gilead Sciences, Inc, and Johnson & Johnson.

Figures

Figure 1.
Figure 1.
Rates of myocardial infarction (MI; left) and rates of MI by age (right) in HIV-infected and HIV-uninfected persons. Adapted from Triant et al.3
Figure 2.
Figure 2.
Effect on weight (left) and inflammatory markers (right) of reducing dietary intake by 500 calories per day for 8 weeks in obese persons. Adapted from Hermsdorff et al.
Figure 3.
Figure 3.
Increasing prevalence of obesity (BMI ≥ 30) from 1990 to 2007 (top) and of diabetes (including gestational diabetes) from 1990 to 2001 (bottom) in the United States. Adapted from Centers for Disease Control and Prevention and Mokdad et al.,
See this image and copyright information in PMC

References

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