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Meta-Analysis
. 2014 Aug 7;9(8):e102841.
doi: 10.1371/journal.pone.0102841. eCollection 2014.

Associations between TNF-α-308A/G polymorphism and susceptibility with dermatomyositis: a meta-analysis

Si Chen  1 , Qian Wang  1 , Ziyan Wu  1 , Qingjun Wu  1 , Ping Li  1 , Yuan Li  1 , Jing Li  1 , Chuiwen Deng  1 , Chanyuan Wu  1 , Lei Gao  2 , Fengchun Zhang  1 , Yongzhe Li  1
Affiliations
Meta-Analysis

Associations between TNF-α-308A/G polymorphism and susceptibility with dermatomyositis: a meta-analysis

Si Chen et al. PLoS One. .

Abstract

Background: Some surveys had inspected the effects of the tumor necrosis factor-α (TNF-α)-308A/G polymorphism on susceptibility to dermatomyositis (DM), and showed mixed results. To briefly review these consequences, a comprehensive meta-analysis was carried out to estimate the relationship between them much more accurately.

Methods: Relevant documents dated to February 2014 were acquired from the PUBMED, MEDLINE, and EMBASE databases. The number of the genotypes and/or alleles for the TNF-α-308A/G in the DM and control subjects was extracted and statistical analysis was conducted using STATA 11.2 software. Summary odds ratios (ORs) with their 95% confidence intervals (95% CIs) were used to calculate the risk of DM with TNF-α-308A/G. Stratified analysis based on ethnicity and control population source was also performed.

Results: 555 patients with DM and 1005 controls from eight published investigations were finally involved in this meta-analysis. Combined analysis revealed that the overall ORs for the TNF-α-308A allele were 2.041 (95% CIs 1.528-2.725, P<0.0001) in DM. Stratification by ethnicity indicated the TNF-α-308A allele polymorphism was found to be significantly associated with DM in Europeans (OR = 1.977, 95% CI 1.413-2.765, P<0.0001). The only study conducted on TNF-α-308A/G polymorphism in Asians could not be used in ethnicity-stratified meta-analysis. Meta-analysis of the AA+AG vs. GG (dominant model) and AA vs. GG (additive model) of this polymorphism revealed a significant association with DM in overall populations and Europeans.

Conclusions: Our meta-analysis demonstrated that the TNF-α-308A/G polymorphism in the TNF gene might contribute to DM susceptibility, especially in European population. However, further studies with large sample sizes and among different ethnicity populations should be required to verify the association.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Flow diagram of included/excluded studies.
Figure 2
Figure 2. Forest plot of the susceptibility of DM associated with TNF-α-308 gene polymorphism.
A: A vs. G, Forest plot; B: AA+AG vs. GG, Forest plot, C: AA vs. GG, D: AA vs. GG+AG.
Figure 3
Figure 3. Forest plot of the susceptibility of DM associated with TNF-α-308 gene polymorphism under stratification.
A: A vs. G, Forest plot; B: AA+AG vs. GG, Forest plot, C: AA vs. GG, D: AA vs. GG+AG.
Figure 4
Figure 4. The results of sensitivity analysis from random-effects estimates. (A allele vs. G allele).
Figure 5
Figure 5. Begg’s funnel plot for publication bias test (AA vs. GG).
See this image and copyright information in PMC

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