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Review
. 2014 Aug 7;10(8):e1004254.
doi: 10.1371/journal.ppat.1004254. eCollection 2014 Aug.

Why HIV virions have low numbers of envelope spikes: implications for vaccine development

John Schiller  1 , Bryce Chackerian  2
Affiliations
Review

Why HIV virions have low numbers of envelope spikes: implications for vaccine development

John Schiller et al. PLoS Pathog. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. What's different about HIV virions?
Surface projections of bovine papillomavirus (BPV), HIV, dengue virus, and influenza virus are shown (not to scale). The images of papillomavirus (PV) and dengue virus were obtained from the Viper database (PMID: 18981051). The image of influenza virus is courtesy of cdc.gov. The HIV image was generously provided by Sriram Subramaniam, National Cancer Institute.
Figure 2
Figure 2. Model for the induction of neutralizing antibodies by high-density versus low-density epitope display.
Black arrows represent antibody species during lineage evolution that are not reactive with self; red arrows represent species that are reactive with self. Inverted blue Ys denote B cell lineages that result in production of a virion binding antibody; red Xs denote deletion or tolerization of a self-reactive B cell lineage.
See this image and copyright information in PMC

References

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