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Comment
. 2014 Nov;24(11):1284-5.
doi: 10.1038/cr.2014.104. Epub 2014 Aug 8.

Expanding the functional role of long noncoding RNAs

Per Johnsson  1 , Kevin V Morris  2
Affiliations
Comment

Expanding the functional role of long noncoding RNAs

Per Johnsson et al. Cell Res. 2014 Nov.

Abstract

New findings bring to light a previously unappreciated mechanism involved in the regulation of the oncoprotein MYC. Interesting observations find that the long noncoding RNA (lncRNA) PVT1 is active in controlling levels of MYC through regulation of MYC protein stability.

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Figures

Figure 1
Figure 1
(A) In normal cells, MYC is targeted by phosphorylation on threonine 58 (Thr58) and becomes destabilized and degraded. (B) In cancer cells, gain of 8q24 promotes the expression of MYC and PVT1. PVT1 interferes with the phosphorylation of Thr58 on MYC, which stabilizes the protein and increases its level.
See this image and copyright information in PMC

Comment on

  • PVT1 dependence in cancer with MYC copy-number increase.
    Tseng YY, Moriarity BS, Gong W, Akiyama R, Tiwari A, Kawakami H, Ronning P, Reuland B, Guenther K, Beadnell TC, Essig J, Otto GM, O'Sullivan MG, Largaespada DA, Schwertfeger KL, Marahrens Y, Kawakami Y, Bagchi A. Tseng YY, et al. Nature. 2014 Aug 7;512(7512):82-6. doi: 10.1038/nature13311. Epub 2014 Jun 22. Nature. 2014. PMID: 25043044 Free PMC article.

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