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Meta-Analysis
. 2014 Aug 8:5:4613.
doi: 10.1038/ncomms5613.

Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

Hansong Wang  1 , Terrilea Burnett  1 , Suminori Kono  2 , Christopher A Haiman  3 , Motoki Iwasaki  4 , Lynne R Wilkens  1 , Lenora W M Loo  1 , David Van Den Berg  3 , Laurence N Kolonel  1 , Brian E Henderson  3 , Temitope O Keku  5 , Robert S Sandler  5 , Lisa B Signorello  6 , William J Blot  7 , Polly A Newcomb  8 , Mala Pande  9 , Christopher I Amos  10 , Dee W West  11 , Stéphane Bézieau  12 , Sonja I Berndt  13 , Brent W Zanke  14 , Li Hsu  8 ; Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO); Noralane M Lindor  1 , Robert W Haile  1 , John L Hopper  1 , Mark A Jenkins  1 , Steven Gallinger  15 , Graham Casey  3 ; Colon Cancer Family Registry (CCFR); Stephanie L Stenzel  3 , Fredrick R Schumacher  1 , Ulrike Peters  8 , Stephen B Gruber  1 ; Colorectal Transdisciplinary Study (CORECT); Shoichiro Tsugane  4 , Daniel O Stram  3 , Loïc Le Marchand  1
Collaborators, Affiliations
Meta-Analysis

Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

Hansong Wang et al. Nat Commun. .

Abstract

The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P<5 × 10(-8)) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.4 × 10(-9)), providing additional insight into the aetiology of CRC and highlighting the value of association mapping in diverse populations.

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Figures

Figure 1
Figure 1. Regional P-value plots for the new colorectal cancer susceptibility locus at 10q25
Results in the Japanese (a) (n = 6,424), African Americans (b) (n = 6,595) and in the combined data (Japanese and African Americans) (c) are displayed. The SNP with the smallest P-value from meta-analysis in the combined data (n = 13,019), rs12241008, is shown as a purple diamond. r2 is in relation to this SNP from the 1000 Genomes Project in East Asians (a,c) or in Africans (b). The plot was generated using LocusZoom.
Figure 1
Figure 1. Regional P-value plots for the new colorectal cancer susceptibility locus at 10q25
Results in the Japanese (a) (n = 6,424), African Americans (b) (n = 6,595) and in the combined data (Japanese and African Americans) (c) are displayed. The SNP with the smallest P-value from meta-analysis in the combined data (n = 13,019), rs12241008, is shown as a purple diamond. r2 is in relation to this SNP from the 1000 Genomes Project in East Asians (a,c) or in Africans (b). The plot was generated using LocusZoom.
Figure 1
Figure 1. Regional P-value plots for the new colorectal cancer susceptibility locus at 10q25
Results in the Japanese (a) (n = 6,424), African Americans (b) (n = 6,595) and in the combined data (Japanese and African Americans) (c) are displayed. The SNP with the smallest P-value from meta-analysis in the combined data (n = 13,019), rs12241008, is shown as a purple diamond. r2 is in relation to this SNP from the 1000 Genomes Project in East Asians (a,c) or in Africans (b). The plot was generated using LocusZoom.
See this image and copyright information in PMC

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