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Review
. 2014 Aug 7;6(8):2991-3018.
doi: 10.3390/v6082991.

The coronavirus nucleocapsid is a multifunctional protein

Ruth McBride  1 , Marjorie van Zyl  2 , Burtram C Fielding  3
Affiliations
Review

The coronavirus nucleocapsid is a multifunctional protein

Ruth McBride et al. Viruses. .

Abstract

The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. Recent studies have confirmed that N is a multifunctional protein. The aim of this review is to highlight the properties and functions of the N protein, with specific reference to (i) the topology; (ii) the intracellular localization and (iii) the functions of the protein.

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Figures

Figure 1
Figure 1
Domain organization of the Severe Acute Respiratory Syndrome human coronavirus (SARS-CoV) nucleocapsid protein. IDR (a.a. 1–44; 182–247; 366–422)—intrinsically disordered regions; NTD (a.a. 45–181)—N terminal domain; LKR (182–247)—linker region; CTD (248–365)—C-terminal domain. The charged SR rich (striated box) and the nuclear localization signal (NLS, solid box) motifs are shown [16,18,19].
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