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Comment
. 2014 Aug 7;15(2):114-6.
doi: 10.1016/j.stem.2014.07.004.

The tailless root of glioma: cancer stem cells

Qi Xie  1 , William A Flavahan  1 , Shideng Bao  1 , Jeremy Rich  2
Affiliations
Comment

The tailless root of glioma: cancer stem cells

Qi Xie et al. Cell Stem Cell. .

Abstract

In this issue of Cell Stem Cell, Zhu et al. (2014) demonstrate that a genetically engineered glioma model displays a functional cellular hierarchy defined by expression of the nuclear orphan receptor Tlx. Targeting cancer stem cells through genetic deletion of TLX promotes cancer stem cell death and differentiation and extends survival.

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Figures

Figure 1
Figure 1. The role of the nuclear orphan receptor TLX (NR2E1) in glioblastoma
TLX-positive glioma cells are quiescent and display the capacity for self-renewal and tumor growth. TLX marks a subpopulation of tumor cells distinct from other putative cancer stem cell (CSC) markers – SOX2 and OLIG2 – suggesting the potential for different pools of CSCs or further stages in a cellular hierarchy with SOX2 potentially indicating a transient amplifying progenitor population
See this image and copyright information in PMC

Comment on

References

    1. Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006 Dec 7;444(7120):756–760. - PubMed
    1. Benod C, Villagomez R, Filgueira CS, Hwang PK, Leonard PG, Poncet-Montange G, Rajagopalan S, Fletterick RJ, Gustafsson JÅ, Webb P. The Human Orphan Nuclear Receptor Tailless (TLX, NR2E1) Is Druggable. PLoS One. 2014 Jun 17;9(6):e99440. - PMC - PubMed
    1. Liu HK, Belz T, Bock D, Takacs A, Wu H, Lichter P, Chai M, Schutz G. The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone. Genes & development. 2008;22:2473–2478. - PMC - PubMed
    1. Liu HK, Wang Y, Belz T, Bock D, Takacs A, Radlwimmer B, Barbus S, Reifenberger G, Lichter P, Schütz G. The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation. Genes Dev. 2010 Apr 1;24(7):683–695. - PMC - PubMed
    1. Park HJ, Kim JK, Jeon HM, Oh SY, Kim SH, Nam DH, Kim H. The neural stem cell fate determinant TLX promotes tumorigenesis and genesis of cells resembling glioma stem cells. Mol Cells. 2010 Nov;30(5):403–408. - PubMed