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Comment
. 2014 Aug 7;15(2):118-20.
doi: 10.1016/j.stem.2014.07.010.

Tipping the balance: MTDH-SND1 curbs oncogene-induced apoptosis and promotes tumorigenesis

Nagarajan Kannan  1 , Connie J Eaves  2
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Tipping the balance: MTDH-SND1 curbs oncogene-induced apoptosis and promotes tumorigenesis

Nagarajan Kannan et al. Cell Stem Cell. .
Free article

Abstract

Tumorigenesis is a complex and poorly understood process in which oncogenes can activate competing proapoptotic and proneoplastic programs. A recent paper in Cancer Cell demonstrates a dual role of the MTDH-SND1 complex in suppressing the apoptotic response and promoting breast cancer development, suggesting a new therapeutic avenue.

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