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Review
. 2014 Dec;37(12):1143-53.
doi: 10.1007/s40618-014-0137-y. Epub 2014 Aug 9.

GLP-1: benefits beyond pancreas

G Muscogiuri  1 , A Cignarelli, F Giorgino, F Prodam, D Santi, G Tirabassi, G Balercia, R Modica, A Faggiano, A Colao
Affiliations
Free article
Review

GLP-1: benefits beyond pancreas

G Muscogiuri et al. J Endocrinol Invest. 2014 Dec.
Free article

Erratum in

  • Erratum to: GLP-1: benefits beyond pancreas.
    Muscogiuri G, Cignarelli A, Giorgino F, Prodam F, Santi D, Tirabassi G, Balercia G, Modica R, Faggiano A, Colao A. Muscogiuri G, et al. J Endocrinol Invest. 2015 Jan;38(1):115. doi: 10.1007/s40618-014-0188-0. J Endocrinol Invest. 2015. PMID: 25362628 No abstract available.

Abstract

Introduction: Glucagon-like peptide 1 (GLP-1) is an intestinal hormone secreted after the ingestion of various nutrients. The main role of GLP-1 is to stimulate insulin secretion in a glucose-dependent manner. However, the expression of GLP-1 receptor was found to be expressed in a variety of tissues beyond pancreas such as lung, stomach, intestine, kidney, heart and brain. Beyond pancreas, a beneficial effect of GLP-1 on body weight reduction has been shown, suggesting its role for the treatment of obesity. In addition, GLP-1 has been demonstrated to reduce cardiovascular risk factors and to have a direct cardioprotective effect, fostering heart recovery after ischemic injury. Further, data from both experimental animal models and human studies have shown beneficial effect of GLP-1 on bone metabolism, either directly or indirectly on bone cells.

Materials and methods: We review here the recent findings of the extra-pancreatic effects of GLP-1 focusing on both basic and clinical studies, thus opening future perspectives to the use of GLP-1 analogs for the treatment of disease beyond type 2 diabetes.

Conclusion: Finally, the GLP-1 has been demonstrated to have a beneficial effect on both vascular, degenerative diseases of central nervous system and psoriasis.

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