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Editorial
. 2014 Nov;98(11):1467-9.
doi: 10.1136/bjophthalmol-2014-305614. Epub 2014 Aug 7.

Ophthalmic Statistics Note 4: analysing data from randomised controlled trials with baseline and follow-up measurements

Rachel Nash  1 , Catey Bunce  2 , Nick Freemantle  3 , Caroline J Doré  4 , Chris A Rogers  1 ; Ophthalmic Statistics Group
Collaborators, Affiliations
Editorial

Ophthalmic Statistics Note 4: analysing data from randomised controlled trials with baseline and follow-up measurements

Rachel Nash et al. Br J Ophthalmol. 2014 Nov.
No abstract available

Keywords: Neovascularisation.

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Figures

Figure 1
Figure 1
Baseline and post-treatment Best Corrected Visual Acuity (BCVA) for the subset of patients with a post-treatment BCVA of more than 50 letters (n=425 patients). The estimated difference in mean BCVA between the two drugs groups from the analysis of covariance is the vertical distance between the two regression lines shown on the plot.
See this image and copyright information in PMC

References

    1. ICH Harmonised Tripartite Guideline. Statistical principles for clinical trials. International Conference on Harmonisation E9 Expert Working Group. Stat Med 1999;18:1905–42. - PubMed
    1. Vickers AJ, Altman DG. Statistics notes: analysing controlled trials with baseline and follow up measurements. BMJ 2001;323:1123–4. - PMC - PubMed
    1. Frison L, Pocock SJ. Repeated measures in clinical trials: analysis using mean summary statistics and its implications for design. Stat Med 1992; 11:1685–704. - PubMed
    1. Van Breukelen GJ. ANCOVA versus change from baseline: more power in randomized studies, more bias in nonrandomized studies [corrected]. J Clin Epidemiol 2006;59:920–5. - PubMed
    1. Chakravarthy U, Harding SP, Rogers CA, et al. Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial. Lancet 2013;382:1258–67. - PubMed

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