Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2014 Sep;21(9):1345-6.
doi: 10.1038/cdd.2014.94.

Dlx genes and the maintenance of bone homeostasis and skeletal integrity

G Levi  1 , Y Gitton  1
Affiliations
Editorial

Dlx genes and the maintenance of bone homeostasis and skeletal integrity

G Levi et al. Cell Death Differ. 2014 Sep.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Summary diagram of the effects of Dlx3 inactivation in osteogenic cells. In osteoblast (lower part of the figure) Dlx3 inhibits the expression of positive regulators of osteogenesis. Dlx3 inactivation results in higher levels of expression of Runx2, Sp7, Dlx5/6, and so on, and increases osteogenesis. Cortical bone osteobalsts of Dlx3−/− mice present also a higher level of expression of Opg, suggesting that, in parallel with increased bone deposition, this bone compartment is also characterized by reduced activity of osteoclasts (upper part of Figure 1). Dlx3 is, therefore, a negative modulator of osteogenesis at multiple levels; its coordinated action with other activators of osteogenesis, such as Dlx5, is required for the maintenance of bone homeostasis
See this image and copyright information in PMC

Comment on

References

    1. Karsenty G, et al. Annu Rev Cell Dev Biol. 2009. pp. 629–648. - PubMed
    1. Boyle WJ, et al. Nature. 2003. pp. 337–342. - PubMed
    1. Negishi-Koga T, Takayanagi H. Immunol Rev. 2009. pp. 241–256. - PubMed
    1. Cohen SM, et al. Nature. 1989. pp. 432–434. - PubMed
    1. O'Hara E, et al. Development. 1993. pp. 847–856. - PubMed

Substances