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. 1989 Sep;8(9):2559-66.
doi: 10.1002/j.1460-2075.1989.tb08394.x.

Autoregulation of fos: the dyad symmetry element as the major target of repression

H König  1 , H Ponta, U Rahmsdorf, M Büscher, A Schönthal, H J Rahmsdorf, P Herrlich
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Autoregulation of fos: the dyad symmetry element as the major target of repression

H König et al. EMBO J. 1989 Sep.

Abstract

Fos and Jun co-operatively repress the fos promoter. Removal of all putative Fos/Jun binding sites from the fos promoter neither obliterates the repression by Fos/Jun in transient cotransfection experiments in NIH3T3 cells nor the turn-off kinetics of serum-induced fos expression in stably transfected NIH3T3 cells. The dyad symmetry element (DSE) suffices to subject a promoter to this type of repression. However, one of the putative Fos/Jun binding sites (-292 to -299 and thus located immediately adjacent to the DSE), determines the very low level of basal expression.

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