Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Aug 7;20(29):9922-35.
doi: 10.3748/wjg.v20.i29.9922.

Helicobacter pylori and oral pathology: relationship with the gastric infection

Isabel Adler  1 , Andrea Muiño  1 , Silvia Aguas  1 , Laura Harada  1 , Mariana Diaz  1 , Adriana Lence  1 , Mario Labbrozzi  1 , Juan Manuel Muiño  1 , Boris Elsner  1 , Alejandra Avagnina  1 , Valeria Denninghoff  1
Affiliations

Helicobacter pylori and oral pathology: relationship with the gastric infection

Isabel Adler et al. World J Gastroenterol. .

Abstract

Helicobacter pylori (H. pylori) has been found in the oral cavity and stomach, and its infection is one of the most frequent worldwide. We reviewed the literature and conducted a Topic Highlight, which identified studies reporting an association between H. pylori-infection in the oral cavity and H. pylori-positive stomach bacterium. This work was designed to determine whether H. pylori is the etiologic agent in periodontal disease, recurrent aphthous stomatitis (RAS), squamous cell carcinoma, burning and halitosis. Record selection focused on the highest quality studies and meta-analyses. We selected 48 articles reporting on the association between saliva and plaque and H. pylori-infection. In order to assess periodontal disease data, we included 12 clinical trials and 1 meta-analysis. We evaluated 13 published articles that addressed the potential association with RAS, and 6 with squamous cell carcinoma. Fourteen publications focused on our questions on burning and halitosis. There is a close relation between H. pylori infection in the oral cavity and the stomach. The mouth is the first extra-gastric reservoir. Regarding the role of H. pylori in the etiology of squamous cell carcinoma, no evidence is still available.

Keywords: Burning and halitosis; Gastric infection; Helicobacter pylori; Oral pathology; Recurrent aphthous stomatitis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Periodontal disease. Helicobacter pylori-positive finding in subgingival plaque and stomach.
Figure 2
Figure 2
Recurrent aphthous stomatitis. Erosive necrotic lesion in lip mucosa. Helicobacter pylori-negative finding by molecular biology.
Figure 3
Figure 3
Oral squamous cell carcinoma grade 2 in lingual dorsum. Helicobacter pylori-negative finding by molecular biology. Biopsy area.
Figure 4
Figure 4
Burning, halitosis, and lingual dorsum hyperplasia. Negative for mycological microscopy and culture. Helicobacter pylori-positive finding in lingual dorsum and stomach.
See this image and copyright information in PMC

References

    1. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984;1:1311–1315. - PubMed
    1. Marshall BJ, Armstrong JA, McGechie DB, Glancy RJ. Attempt to fulfil Koch’s postulates for pyloric Campylobacter. Med J Aust. 1985;142:436–439. - PubMed
    1. Wroblewski LE, Peek RM, Wilson KT. Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev. 2010;23:713–739. - PMC - PubMed
    1. Nabwera HM, Logan RP. Epidemiology of Helicobacter pylori: transmission, translocation and extragastric reservoirs. J Physiol Pharmacol. 1999;50:711–722. - PubMed
    1. Hunt RH, Xiao SD, Megraud F, Leon-Barua R, Bazzoli F, van der Merwe S, Vaz Coelho LG, Fock M, Fedail S, Cohen H, et al. Helicobacter pylori in developing countries. World Gastroenterology Organisation Global Guidelines. 2010 - PubMed

MeSH terms