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. 2014 Aug 7;20(29):10144-50.
doi: 10.3748/wjg.v20.i29.10144.

Trends in incidence and management of cancer of the ampulla of Vater

Florian Rostain  1 , Samia Hamza  1 , Antoine Drouillard  1 , Jean Faivre  1 , Anne-Marie Bouvier  1 , Côme Lepage  1
Affiliations

Trends in incidence and management of cancer of the ampulla of Vater

Florian Rostain et al. World J Gastroenterol. .

Abstract

Aim: To provide trends in incidence, management and survival of cancer of the ampulla of Vater in a well-defined French population.

Methods: Data were obtained from the population-based digestive cancer registry of Burgundy over a 34-year period. Age-standardized incidence rates were computed using the world standard population. Average annual variations in incidence rates were estimated using a poisson regression. A univariate and multivariate relative survival analysis was performed.

Results: Age-standardized incidence rates were 0.46 and 0.30 per 100000 inhabitants for men and women, respectively. Incidence rate increased from 0.26 (1976-1984) to 0.58 (2003-2009) for men and remained stable for women. Resection for cure was performed in 48.3% of cases. This proportion was stable over the study period. Among cases with curative resection, pancreatico-duodenectomy was performed in 94.0% of cases and ampullectomy in 6.0% of cases. A total of 50.8% of cancers of the ampulla of Vater were diagnosed at an advanced stage. Their proportion remained stable throughout the study period. The overall 1- and 5-year relative survival rates were 60.2% and 27.7%, respectively. Relative survival did not vary over time. Treatment and stage at diagnosis were the most important determinants of survival. The 5-year relative survival rate was 41.5% after resection for cure, 9.5% after palliative surgery and 6.7% after symptomatic treatment. In multivariate analysis, only stage at diagnosis significantly influenced the risk of death.

Conclusion: Cancer of the ampulla of Vater is still uncommon, but its incidence increased for men in Burgundy. Diagnosis is often made at an advanced stage, dramatically worsening the prognosis.

Keywords: Cancer of the ampulla of Vater; Epidemiology; Incidence; Survival; Treatment.

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Figures

Figure 1
Figure 1
Age-specific incidence of cancer of the ampulla of Vater.
Figure 2
Figure 2
Cancer of ampulla of Vater survival rate according to node status.
See this image and copyright information in PMC

References

    1. Goodman MT, Yamamoto J. Descriptive study of gallbladder, extrahepatic bile duct, and ampullary cancers in the United States, 1997-2002. Cancer Causes Control. 2007;18:415–422. - PubMed
    1. Urbach DR, Swanstrom LL, Khajanchee YS, Hansen PD. Incidence of cancer of the pancreas, extrahepatic bile duct and ampulla of Vater in the United States, before and after the introduction of laparoscopic cholecystectomy. Am J Surg. 2001;181:526–528. - PubMed
    1. Beger HG, Treitschke F, Gansauge F, Harada N, Hiki N, Mattfeldt T. Tumor of the ampulla of Vater: experience with local or radical resection in 171 consecutively treated patients. Arch Surg. 1999;134:526–532. - PubMed
    1. Yoon YS, Kim SW, Park SJ, Lee HS, Jang JY, Choi MG, Kim WH, Lee KU, Park YH. Clinicopathologic analysis of early ampullary cancers with a focus on the feasibility of ampullectomy. Ann Surg. 2005;242:92–100. - PMC - PubMed
    1. Lee SY, Jang KT, Lee KT, Lee JK, Choi SH, Heo JS, Paik SW, Rhee JC. Can endoscopic resection be applied for early stage ampulla of Vater cancer? Gastrointest Endosc. 2006;63:783–788. - PubMed

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