Multidrug-resistant tuberculosis treatment with linezolid-containing regimen
- PMID: 25110635
- PMCID: PMC4123797
- DOI: 10.1016/j.ijmyco.2013.09.002
Multidrug-resistant tuberculosis treatment with linezolid-containing regimen
Abstract
The following is a case of multidrug-resistant pulmonary tuberculosis (MDR-TB) that was treated successfully with a linezolid-containing regimen. It was found that linezolid is an efficient medicine for MDR-TB treatment with an acceptable side effect profile. Treatment was maintained for 18 months, and closely monitoring toxicities did not reveal evidence of any neurologic adverse effects. However, despite our expectation, thrombocytopenia was seen after 2 years follow-up.
Keywords: Linezolid; Multidrug-resistant tuberculosis; Thrombocytopenia; Treatment.
Conflict of interest statement
None.
References
-
- Guidance for National Tuberculosis Programmes on the management of tuberculosis in children. Chapter 1: Introduction and diagnosis of tuberculosis in children. Int J Tuberc Lung Dis. 2006;10(10):1091–1097. - PubMed
-
- Falzon D, Jaramillo E, Schunemann HJ, et al. WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update. Eur Respir J. 2011;38(3):516–528. - PubMed
-
- Chan ED, Laurel V, Strand MJ, et al. Treatment and outcome analysis of 205 patients with multidrug-resistant tuberculosis. Am J Respir Crit Care Med. 2004;169(10):1103–1109. - PubMed
-
- Chang KC, Yew WW. Management of difficult multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis: update 2012. Respirology. 2013;18(1):8–21. - PubMed
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