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. 1989 Aug;51(3):339-41.
doi: 10.1016/0378-1097(89)90421-7.

Transient exposure to a physiologically-relevant concentration of calcium confers tobramycin resistance upon sessile cells of Pseudomonas aeruginosa

B D Hoyle  1 , J W Costerton
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Transient exposure to a physiologically-relevant concentration of calcium confers tobramycin resistance upon sessile cells of Pseudomonas aeruginosa

B D Hoyle et al. FEMS Microbiol Lett. 1989 Aug.

Abstract

Sessile populations of a mucoid Pseudomonas aeruginosa isolate generated in M-56 medium of 'low' (0.02 mM) or 'high' (2.5 mM) Ca2+ were treated with tobramycin (250 micrograms.ml-1), as were biofilms exposed transiently to 'high' Ca2+ medium. Viability decreased by over 99.9% within 8 h in the 'low' and 'high' samples, while transient Ca2+ exposure was protective. Dispersed sessile bacteria were as tobramycin sensitive as planktonic bacteria.

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