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Review
. 2014 Oct;47(5):381-90.
doi: 10.1111/cpr.12121. Epub 2014 Aug 11.

Cell and molecular biology of intervertebral disc degeneration: current understanding and implications for potential therapeutic strategies

S Z Wang  1 , Y F Rui, J Lu, C Wang
Affiliations
Review

Cell and molecular biology of intervertebral disc degeneration: current understanding and implications for potential therapeutic strategies

S Z Wang et al. Cell Prolif. 2014 Oct.

Abstract

Intervertebral disc degeneration (IDD) is a chronic, complex process associated with low back pain; mechanisms of its occurrence have not yet been fully elucidated. Its process is not only accompanied by morphological changes, but also by systematic changes in its histological and biochemical properties. Many cellular and molecular mechanisms have been reported to be related with IDD and to reverse degenerative trends, abnormal conditions of the living cells and altered cell phenotypes would need to be restored. Promising biological therapeutic strategies still rely on injection of active substances, gene therapy and cell transplantation. With advanced study of tissue engineering protocols based on cell therapy, combined use of seeding cells, bio-active substances and bio-compatible materials, are promising for IDD regeneration. Recently reported progenitor cells within discs themselves also hold prospects for future IDD studies. This article describes the background of IDD, current understanding and implications of potential therapeutic strategies.

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Figures

Figure 1
Figure 1
Sagittal structure and homoeostasis of the intervertebral disc.
See this image and copyright information in PMC

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