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. 1989 Dec;63(12):5086-91.
doi: 10.1128/JVI.63.12.5086-5091.1989.

Dengue virus-specific cross-reactive CD8+ human cytotoxic T lymphocytes

J F Bukowski  1 , I Kurane, C J Lai, M Bray, B Falgout, F A Ennis
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Dengue virus-specific cross-reactive CD8+ human cytotoxic T lymphocytes

J F Bukowski et al. J Virol. 1989 Dec.

Abstract

Stimulation with live dengue virus of peripheral blood mononuclear cells from a dengue virus type 4-immune donor generated virus-specific, serotype-cross-reactive, CD8+, class I-restricted cytotoxic T lymphocytes (CTL) capable of lysing dengue virus-infected cells and cells pulsed with dengue virus antigens of all four serotypes. These CTL lysed autologous fibroblasts infected with vaccinia virus-dengue virus recombinant viruses containing the E gene or several nonstructural dengue virus type 4 genes. These results demonstrate that both dengue virus structural and nonstructural proteins are targets for the cytotoxic T-cell-mediated immune response to dengue virus and suggest that serotype-cross-reactive CD8+ CTL may be important mediators of viral clearance and of virus-induced immunopathology during secondary dengue virus infections.

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References

    1. J Exp Med. 1977 Jul 1;146(1):201-17 - PubMed
    1. Tissue Antigens. 1976 Mar;7(3):165-72 - PubMed
    1. Am J Epidemiol. 1981 Nov;114(5):632-48 - PubMed
    1. J Immunol. 1982 Aug;129(2):844-9 - PubMed
    1. Am J Trop Med Hyg. 1983 Jan;32(1):157-63 - PubMed

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