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Review
. 2014 Oct;11(4):732-7.
doi: 10.1007/s13311-014-0295-9.

Genetics of Alzheimer's disease

Rita Guerreiro  1 , John Hardy
Affiliations
Review

Genetics of Alzheimer's disease

Rita Guerreiro et al. Neurotherapeutics. 2014 Oct.

Abstract

The analyses of genetic factors contributing to Alzheimer's disease (AD) and other dementias have evolved at the same pace as genetic and genomic technologies are developed and improved. The identification of the first genes involved in AD arose from family-based studies, but risk factors have mainly been identified by studies comparing groups of patients with groups of controls. The best outcomes have been heavily associated with the capacity of interrogating genetic variability at the genome level without any particular a priori hypothesis. In this review we assess the role of genetic family studies in Alzheimer's disease and other dementias within the current status of dementias' and, particularly, AD's genetic architecture.

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Figures

Fig. 1
Fig. 1
Homozygosity analysis in a family using SNP arrays
See this image and copyright information in PMC

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