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. 2014 Jun;5(2):161-3.
doi: 10.1007/s13193-014-0297-4. Epub 2014 Feb 27.

Steatohepatitic hepatocellular carcinoma-a case report with literature review

Nalini Gupta  1 , Archana Rastogi  2 , Chhagan Bihari  2
Affiliations

Steatohepatitic hepatocellular carcinoma-a case report with literature review

Nalini Gupta et al. Indian J Surg Oncol. 2014 Jun.

Abstract

We report a case of a 65 year old male who presented with complaints of pain right upper abdomen for past 3 months. He was a known diabetic and hypertensive. On evaluation he was found to have space occupying lesion in the right lobe of the liver. USG Guided FNC done showed a Hepatocellular Carcinoma with predominant steatosis. He underwent Right Hepetectomy for the same and Histopathological examination revealed a Steatohepatitic Hepatocellular Carcinoma with background liver showing minimal steatosis and no significant fibrosis. This case is reported to provide better insight into the understanding of pathophysiology of metabolic syndrome as an etiological agent for development of HCC.

Keywords: Hepatocellular Carcinoma (HCC); Metabolic syndrome; Non alchohalic fatty liver disease (NAFLD); Non alchohalic steatohepatitis (NASH); Steatohepatitic Hepatocellular Carcinoma (SH-HCC).

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Figures

Fig. 1
Fig. 1
MRI scan showing a well marginated mass in right lobe of liver
Fig. 2
Fig. 2
Cytological Smears showing atypical epithelial cell with pleomorphic nuclei, prominent nucleoli and moderate cytoplasm with steatosis (Geimsa × 40)
Fig. 3
Fig. 3
Histopathological examination showing neoplastic hepatocytes with moderate steatosis and ballooning degeneration (H & E × 10)
Fig. 4
Fig. 4
Immunohistochemical staining for Glutamine Synthatase (Original magnification × 10)
See this image and copyright information in PMC

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