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Case Reports
. 2014 Jul 21:8:447.
doi: 10.3332/ecancer.2014.447. eCollection 2014.

Spindle cell carcinoma of the tongue: a rare variant of squamous cell carcinoma

Manisha V Biradar  1 , Sunita S Dantkale  1 , Rahul S Abhange  1 , Hemlata T Kamra  1 , Khushboo Birla  1
Affiliations
Case Reports

Spindle cell carcinoma of the tongue: a rare variant of squamous cell carcinoma

Manisha V Biradar et al. Ecancermedicalscience. .

Abstract

Spindle cell carcinoma (SpCC), a rare, aggressive variant of squamous cell carcinoma (SCC), is characterised by proliferation of epithelial and mesenchymal components. It is important to diagnose this variant of SCC, because of its tendency to recur and early metastasis. It accounts for 1% of all tumours in the oral cavity. In this paper, we have reported a case of SpCC of the tongue in a 65-year-old male who presented with a polypoidal growth over the lateral border of his tongue with a short history of one month. Immunohistochemical expression of cytokeratin was strongly positive in the epithelial component and focally in the spindle cell component. The spindle cell component showed a strong positivity for vimentin.

Keywords: biphasic; epithelial; mesenchymal; spindle cell; squamous.

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Figures

Figure 1.
Figure 1.. Gross-grey white mass.
Figure 2.
Figure 2.. M/E showing squamous and spindle cell component (H & E Stain; 10×).
Figure 3.
Figure 3.. M/E showing spindle cells arranged in fascicles (H & E Stain; 10×).
Figure 4.
Figure 4.. M/E showing spindle cell component (H & E Stain; 40×).
Figure 5.
Figure 5.. M/E showing epithelial pearl (H & E Stain; 10×).
Figure 6.
Figure 6.. IHC showing spindle cells strongly positive for vimentin (10×).
Figure 7.
Figure 7.. IHC showing spindle cells focal positivity for cytokeratin (10×).
Figure 8.
Figure 8.. IHC showing squamous cells positive for cytokeratin (10×).
See this image and copyright information in PMC

References

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