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. 2014 Aug 4:13:79.
doi: 10.1186/2251-6581-13-79. eCollection 2014.

Diabetic foot risk factors in type 2 diabetes patients: a cross-sectional case control study

Piotr Nehring  1 , Beata Mrozikiewicz-Rakowska  1 , Monika Krzyżewska  1 , Agnieszka Sobczyk-Kopcioł  2 , Rafał Płoski  3 , Grażyna Broda  4 , Waldemar Karnafel  1
Affiliations

Diabetic foot risk factors in type 2 diabetes patients: a cross-sectional case control study

Piotr Nehring et al. J Diabetes Metab Disord. .

Abstract

Background: Diabetic foot is a serious condition in patients with a long lasting diabetes mellitus. Diabetic foot treated improperly may lead not only to delayed ulceration healing, generalized inflammation, unnecessary surgical intervention, but also to the lower limb amputation. The aim of this study was to compare diabetic foot risk factors in population with type 2 diabetes and risk factors for diabetes in healthy subjects.

Methods: The study included 900 subjects: 145 with diabetic foot, 293 with type 2 diabetes without diabetic foot and 462 healthy controls matched in terms of mean age, gender structure and cardiovascular diseases absence. Study was conducted in Gastroenterology and Metabolic Diseases Department, Medical University of Warsaw, Poland. In statistical analysis a logistic regression model, U Mann-Whitney's and t-Student test were used.

Results: The binomial logit models analysis showed that the risk of diabetic foot in patients with type 2 diabetes was decreased by patient's age (odds ratio [OR] = 0.94; 95% confidence interval [CI]: 0.92-0.96; p = 0.00001) and hyperlipidaemia (OR = 0.54; 95% CI: 0.36-0.81; p = 0.01). In contrast, male gender (OR = 2.83; 95% CI: 1.86-4.28; p = 0.00001) diabetes duration (OR = 1.04; 95% CI: 1.03-1.06; p = 0.0003), weight (OR = 1.04; 95% CI: 1.03-1.06; p = 0.00001), height (OR = 1.08; 95% CI: 1.05-1.11; p = 0.00001) and waist circumference (OR = 1.028; 95% CI: 1.007-1.050; p = 0.006) increase the risk of diabetic foot. The onset of type 2 diabetes in healthy subjects was increased by weight (OR = 1.035; 95% CI: 1.024-1.046; p = 0.00001), WC (OR = 1.075; 95% CI: 1.055-1.096; p = 00001), hip circumference (OR = 1.03; 95% CI: 1.01-1.05; p = 0.005), overweight defined with body mass index (BMI) above 24,9 kg/m(2) (OR = 2.49; 95% CI: 1.77-3.51; p = 0.00001) and hyperlipidaemia (OR = 3.53; 95% CI: 2.57-4.84; p = 0.00001).

Conclusions: Risk factors for Type 2 diabetes and diabetic foot are only partially common. Study proved that patients who are prone to developing diabetic foot experience different risk factors than patients who are at risk of diabetes. Identification of relationship between diabetic foot and diabetes risk factors in appropriate groups may help clinicians to focus on certain factors in diabetic foot prevention.

Keywords: Diabetes; Diabetic foot; Epidemiology; Type 2 diabetes.

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Figures

Figure 1
Figure 1
The gender structure of patients with diabetic foot and type 2 diabetes group.
Figure 2
Figure 2
Number of BMI over and below 24.9 kg/m 2 in patients with type 2 diabetes and in healthy controls.
See this image and copyright information in PMC

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