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Review
. 2014 Sep;31(9):1115-37.
doi: 10.1007/s10815-014-0280-6. Epub 2014 Aug 13.

A multi-faceted approach to understanding male infertility: gene mutations, molecular defects and assisted reproductive techniques (ART)

Eisa Tahmasbpour  1 , Dheepa Balasubramanian, Ashok Agarwal
Affiliations
Review

A multi-faceted approach to understanding male infertility: gene mutations, molecular defects and assisted reproductive techniques (ART)

Eisa Tahmasbpour et al. J Assist Reprod Genet. 2014 Sep.

Abstract

Background: The assisted reproductive techniques aimed to assist infertile couples have their own offspring carry significant risks of passing on molecular defects to next generations.

Results: Novel breakthroughs in gene and protein interactions have been achieved in the field of male infertility using genome-wide proteomics and transcriptomics technologies.

Conclusion: Male Infertility is a complex and multifactorial disorder.

Significance: This review provides a comprehensive, up-to-date evaluation of the multifactorial factors involved in male infertility. These factors need to be first assessed and understood before we can successfully treat male infertility.

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Figures

Fig. 1
Fig. 1
Common genetic, molecular and epigenetic factors contributing to the development, and the diagnostic and preventive measures to treat male infertility
Fig. 2
Fig. 2
A schematic picture of Y chromosome displaying AZF regions (AZFa-c) and associated genes. Enlarged portion of AZFc region illustrates the discussed microdeletions. (a) Normal AZFc region, (b) gr/gr deletion, (c) b1/b3 deletion, and (d) b2/b3 deletion
See this image and copyright information in PMC

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