. 2014 Dec:73:135-42.

doi: 10.1016/j.envint.2014.06.020. Epub 2014 Aug 10.

Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys

Affiliations

¹ Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA; Quintiles, Cambridge, MA, USA.
² Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
³ Pediatric Endocrine Division, Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA, USA; Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, USA.
⁴ Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁵ National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
⁶ Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA.
⁷ Samara State Medical University, Department of Physical Education and Health, Samara, Russia; Chapaevsk Medical Association, Chapaevsk, Samara Region, Russia.
⁸ Institute for Forecasting, Russian Academy of Sciences, Moscow, Russia.
⁹ Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA; Environmental Health and Engineering, Inc., Needham, MA, USA.
¹⁰ EnviroSolutions Consulting, Inc., Auburn, GA, USA; Axys Analytical Solutions, Sidney, BC, Canada; Exponent, Inc., Maynard, MA, USA.
¹¹ Centers for Disease Control and Prevention, Atlanta, GA, USA.
¹² Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. Electronic address: rhauser@hsph.harvard.edu.

PMID: 25118086
PMCID: PMC4194160
DOI: 10.1016/j.envint.2014.06.020

Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys

Thuy Lam et al. Environ Int. 2014 Dec.

. 2014 Dec:73:135-42.

doi: 10.1016/j.envint.2014.06.020. Epub 2014 Aug 10.

Authors

Affiliations

¹ Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA; Quintiles, Cambridge, MA, USA.
² Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
³ Pediatric Endocrine Division, Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA, USA; Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, USA.
⁴ Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁵ National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
⁶ Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA.
⁷ Samara State Medical University, Department of Physical Education and Health, Samara, Russia; Chapaevsk Medical Association, Chapaevsk, Samara Region, Russia.
⁸ Institute for Forecasting, Russian Academy of Sciences, Moscow, Russia.
⁹ Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA; Environmental Health and Engineering, Inc., Needham, MA, USA.
¹⁰ EnviroSolutions Consulting, Inc., Auburn, GA, USA; Axys Analytical Solutions, Sidney, BC, Canada; Exponent, Inc., Maynard, MA, USA.
¹¹ Centers for Disease Control and Prevention, Atlanta, GA, USA.
¹² Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. Electronic address: rhauser@hsph.harvard.edu.

PMID: 25118086
PMCID: PMC4194160
DOI: 10.1016/j.envint.2014.06.020

Abstract

Background: In animal studies, organochlorine pesticide (OCP) exposure alters pubertal development; however, epidemiological data are limited and inconsistent.

Objective: To evaluate the associations of serum OCP concentrations [hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE)] with male pubertal onset.

Methods: In Chapaevsk, Russia, a town environmentally contaminated with OCPs, 350 8-9 year old boys with measured OCPs were enrolled during 2003-2005 and were followed annually for eight years. We evaluated three measures of pubertal onset: testicular volume (TV)>3 mL in either testis, or stage 2 or greater for genitalia (G2+), or pubic hair (P2+). We used multivariable interval-censored models to evaluate associations of OCPs (quartiles) with physician-assessed pubertal onset.

Results: In adjusted models, boys with higher HCB concentrations had later mean ages of TV>3 mL and P2+ (but not G2+). Mean age at attaining TV>3 mL was delayed 3.6 (95% CI: -2.6, 9.7), 7.9 (95% CI: 1.7, 14.0), and 4.7 months (95% CI: -1.4, 10.9) for HCB Q2, Q3, and Q4, respectively, compared to Q1 (trend p: 0.06). Boys with higher HCB concentrations reached P2+ 0.1 months earlier (95% CI: -5.8, 5.6) for Q2, 4.7 months later (95% CI: -1.0, 10.3) for Q3 and 4.6 months later (95% CI: -1.1, 10.3) for Q4 compared to Q1 (trend p: 0.04). There were no associations of serum β-HCH and p,p'-DDE concentrations with age of pubertal onset.

Conclusion: Higher prepubertal serum HCB concentrations were associated with later age of gonadarche and pubarche.

Keywords: HCB; Male puberty; Organochlorine pesticides; p,p′-DDE; β-HCH.

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Conflict of interest statement

Conflict of Interest Statement: The opinions expressed in this article are those of the authors and do not necessarily reflect the official opinion of the Centers for Disease Control and Prevention. The authors have no conflicts of interest to disclose.

Figures

**Figure 1. Adjusted Mean Shifts in Age at Pubertal Onset (Months, 95% CIs) by Quartiles of Wet-Weight Serum OCP Concentrations Among 350 Russian Boys^a,b,c**
*p ≤ 0.05 **p ≤ 0.10 Shift in months is relative to Q1 (reference) ^aG2+ model adjusted for baseline covariates: boys’ total serum lipids, birth weight, macronutrients (total caloric intake, percent calories from dietary carbohydrates, fat, and protein), blood lead levels; missing birth weight (n=1), macronutrients (n=3) ^bTV > 3 mL model adjusted for baseline covariates: boys’ total serum lipids, birth weight, macronutrients (total caloric intake, percent calories from dietary carbohydrates, fat, and protein), blood lead levels; missing birth weight (n=1), macronutrients (n=3) ^cP2+ model adjusted for baseline covariates: boys’ total serum lipids, macronutrients (total caloric intake, percent calories from dietary carbohydrates, fat, and protein), blood lead levels, maternal age at birth, household income; missing macronutrients (n=3), household income (n=1), maternal age at birth (n=2) ^dHCB wet-weight quartiles (Q1–Q4, pg/g serum): Q1: 169–516; Q2: 517–751; Q3: 752–1,156; Q4: 1,157–15,482 ^eβ-HCH wet-weight quartiles (Q1–Q4, pg/g serum): Q1: 209–567; Q2: 568–814; Q3:815–1,294 Q4: 1,295–13,732 ^fp,p′-DDE wet-weight quartiles (Q1–Q4, pg/g serum): Q1: 261–907; Q2: 908–1,406; Q3: 1,407–2,327; Q4: 2,328–41,301

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Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys

Affiliations

Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical