Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Aug 26;111(34):12278-9.
doi: 10.1073/pnas.1412946111. Epub 2014 Aug 12.

Fungal polyketide engineering comes of age

Vinayak Agarwal  1 , Bradley S Moore  2
Affiliations
Comment

Fungal polyketide engineering comes of age

Vinayak Agarwal et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Combinatorial swapping of hrPKS and nrPKS enzymes that constitute a BDL biosynthetic iPKS leads to production of engineered BDLs. Physiological products of two BDL iPKSs are shown in green (trans-resorcylide) and red (10,11-dehydrocurvularin). On heterologous expression of different combinations of hrPKSs and nrPKSs, different nonnatural BDLs were synthesized (shown in mixed colors).
See this image and copyright information in PMC

Comment on

References

    1. Chooi YH, Tang Y. Navigating the fungal polyketide chemical space: From genes to molecules. J Org Chem. 2012;77(22):9933–9953. - PMC - PubMed
    1. Wiemann P, Keller NP. Strategies for mining fungal natural products. J Ind Microbiol Biotechnol. 2014;41(2):301–313. - PubMed
    1. Schümann J, Hertweck C. Advances in cloning, functional analysis and heterologous expression of fungal polyketide synthase genes. J Biotechnol. 2006;124(4):690–703. - PubMed
    1. Weissman KJ, Leadlay PF. Combinatorial biosynthesis of reduced polyketides. Nat Rev Microbiol. 2005;3(12):925–936. - PubMed
    1. Butler MS. The role of natural product chemistry in drug discovery. J Nat Prod. 2004;67(12):2141–2153. - PubMed

MeSH terms

LinkOut - more resources