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Review
. 2014 Oct;21(5):363-71.
doi: 10.1097/MED.0000000000000100.

Postoperative radioactive iodine administration for differentiated thyroid cancer patients

Charlotte Lepoutre-Lussey  1 , Désirée Deandreis, Sophie Leboulleux, Martin Schlumberger
Affiliations
Review

Postoperative radioactive iodine administration for differentiated thyroid cancer patients

Charlotte Lepoutre-Lussey et al. Curr Opin Endocrinol Diabetes Obes. 2014 Oct.

Abstract

Purpose of review: Radioactive iodine (RAI) is administered postoperatively to the majority of thyroid cancer patients. No available study has demonstrated any benefit in low-risk patients.

Recent findings: RAI should be used selectively in low and intermediate-risk patients, based on the surgical and pathological reports and on postoperative serum thyroglobulin level and neck ultrasonography. When used, a low activity (30 mCi) is administered following recombinant human thyrotropin stimulation. High-risk patients are treated with a high activity of RAI (100 mCi or more).

Summary: RAI is not administered in many low-risk patients who can be reliably followed up with serum thyroglobulin determination on L-thyroxine treatment and neck ultrasonography. RAI may be administered in case of abnormality, and this delay will not reduce the chance of cure.

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