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Review
. 2014 Aug 12;15(8):13993-4013.
doi: 10.3390/ijms150813993.

Current status of long non-coding RNAs in human cancer with specific focus on colorectal cancer

Maria Smolle  1 , Stefan Uranitsch  2 , Armin Gerger  3 , Martin Pichler  4 , Johannes Haybaeck  5
Affiliations
Review

Current status of long non-coding RNAs in human cancer with specific focus on colorectal cancer

Maria Smolle et al. Int J Mol Sci. .

Abstract

The latest investigations of long non-coding RNAs (lncRNAs) have revealed their important role in human cancers. LncRNAs are larger than 200 nucleotides in length and fulfill their cellular purpose without being translated into proteins. Though the molecular functions of some lncRNAs have been elucidated, there is still a high number of lncRNAs with unknown or controversial functions. In this review, we provide an overview of different lncRNAs and their role in human cancers. In particular, we emphasize their importance in tumorigenesis of colorectal cancer, the third most common cancer worldwide.

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Figures

Figure 1
Figure 1
LncRNAs being involved in molecular pathogenesis of colorectal cancer: lncRNAs interact with specific molecular structures, induce different effects in tumor cells and influence the molecular pathogenesis of colorectal cancer.
See this image and copyright information in PMC

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