Getting rid of the bad apple: inflammasome-induced extrusion of Salmonella-infected enterocytes
- PMID: 25121744
- DOI: 10.1016/j.chom.2014.07.010
Getting rid of the bad apple: inflammasome-induced extrusion of Salmonella-infected enterocytes
Abstract
Two reports in this issue of Cell Host & Microbe (Sellin et al., 2014; Knodler et al., 2014) establish the cell-intrinsic inflammasome-induced extrusion of infected enterocytes as a general defense mechanism against acute bacterial infections.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa.Cell Host Microbe. 2014 Aug 13;16(2):237-248. doi: 10.1016/j.chom.2014.07.001. Cell Host Microbe. 2014. PMID: 25121751
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Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens.Cell Host Microbe. 2014 Aug 13;16(2):249-256. doi: 10.1016/j.chom.2014.07.002. Cell Host Microbe. 2014. PMID: 25121752 Free PMC article.
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