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. 2014 Oct;52(10):3805-7.
doi: 10.1128/JCM.01537-14. Epub 2014 Aug 13.

Evaluation of the nanosphere Verigene BC-GN assay for direct identification of gram-negative bacilli and antibiotic resistance markers from positive blood cultures and potential impact for more-rapid antibiotic interventions

Joseph T Hill  1 , Kim-Dung T Tran  1 , Karen L Barton  2 , Matthew J Labreche  2 , Susan E Sharp  3
Affiliations

Evaluation of the nanosphere Verigene BC-GN assay for direct identification of gram-negative bacilli and antibiotic resistance markers from positive blood cultures and potential impact for more-rapid antibiotic interventions

Joseph T Hill et al. J Clin Microbiol. 2014 Oct.

Abstract

The Verigene BC-GN assay correctly identified all 51 Gram-negative bacilli (GNB) from positive blood cultures and all 14 carbapenemase enzymes tested. The assay gave organism identification (ID) results an average of 24 h faster compared to conventional identifications. Medical management could have been modified for 31.8% of patients an average 33 h sooner. In conclusion, the BC-GN assay is a very accurate, rapid assay which would allow for more-immediate medical management decisions in patients with bacteremia from GNB.

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References

    1. Bearman GM, Wenzel RP. 2005. Bacteremias: a leading cause of death. Arch. Med. Res. 36:646–659. 10.1016/j.arcmed.2005.02.005 - DOI - PubMed
    1. Ibrahim EH, Sherman G, Ward S, Fraser VJ, Kollef MH. 2000. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest 118:146–155. 10.1378/chest.118.1.146 - DOI - PubMed
    1. Stryjewski ME, Boucher HW. 2009. Gram-negative bloodstream infections. Int. J. Antimicrob. Agents 34(Suppl 4):S21–S25. 10.1016/S0924-8579(09)70561-8 - DOI - PubMed
    1. Nanosphere, Inc. 2014. Verigene® Gram-Negative blood culture nucleic acid test (BC-GN) product insert. Revision A. Nanosphere, Inc., Northfield, IL
    1. Bauer KA, West JE, Balada-Llasat JM, Pancholi P, Stevenson KB, Goff DA. 2010. An antimicrobial stewardship program's impact with rapid polymerase chain reaction methicillin-resistant Staphylococcus aureus/S. aureus blood culture test in patients with S. aureus bacteremia. Clin. Infect. Dis. 51:1074–1080. 10.1086/656623 - DOI - PubMed

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