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. 2014 Nov;52(11):4020-2.
doi: 10.1128/JCM.01944-14. Epub 2014 Aug 13.

Predictive value of testing nasopharyngeal samples for respiratory viruses in the setting of lower respiratory tract disease

Morgan Hakki  1 , Lynne M Strasfeld  2 , John M Townes  2
Affiliations

Predictive value of testing nasopharyngeal samples for respiratory viruses in the setting of lower respiratory tract disease

Morgan Hakki et al. J Clin Microbiol. 2014 Nov.

Abstract

To determine the predictive value of nasopharyngeal (NP) sample testing for respiratory viruses (RVs) in suspected lower respiratory tract disease, 72 paired NP and bronchoalveolar lavage (BAL) fluid specimen sets, mostly from transplant recipients or patients with hematologic malignancies, were analyzed. Overall, 31.3% of the specimens tested positive for an RV. In 19 sets (26.4%), the NP and BAL fluid specimens were both positive for an RV; in 3 sets (4.2%), the NP specimens were positive but the BAL fluid specimens were negative; and in 3 other sets, the NP specimens were negative but the BAL fluid specimens were positive. The positive and negative predictive values of the NP specimens were 86.4% and 94%, respectively.

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