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Review
. 2014 Oct;35(10):9487-95.
doi: 10.1007/s13277-014-2482-z. Epub 2014 Aug 16.

Caveolin-1 in oral squamous cell carcinoma microenvironment: an overview

Samapika Routray  1
Affiliations
Free article
Review

Caveolin-1 in oral squamous cell carcinoma microenvironment: an overview

Samapika Routray. Tumour Biol. 2014 Oct.
Free article

Abstract

Caveolin-1 plays an important role in the pathogenesis of oncogenic cell transformation, tumorigenesis, and metastasis. Increased expression of caveolin-1 in an array of tumors has confirmed its value in prognosis. It has been established that oxidative stress is the main cause for loss of stromal caveolin-1 via autophagy in the tumor microenvironment. In this overview, we attempt to abridge the relationship between caveolin-1 and oral squamous cell carcinoma, taking all the established theories into consideration.

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