Increased blood glucose is related to disturbed cerebrovascular pressure reactivity after traumatic brain injury
- PMID: 25124103
- DOI: 10.1007/s12028-014-0042-4
Increased blood glucose is related to disturbed cerebrovascular pressure reactivity after traumatic brain injury
Abstract
Background: Increased blood glucose and impaired pressure reactivity (PRx) after traumatic brain injury (TBI) are both known to correlate with unfavorable patient outcome. However, the relationship between these two variables is unknown.
Methods: To test the hypothesis that increased blood glucose leads to increased PRx, we retrospectively analyzed data from 86 traumatic brain injured patients admitted to the Neurocritical Care Unit. Data analyzed included arterial glucose concentration, intracranial pressure (ICP), cerebral perfusion pressure (CPP) and end-tidal CO2. PRx was calculated as the moving correlation coefficient between averaged (10 seconds) arterial blood pressure and ICP. One arterial glucose concentration and one time-aligned PRx value were obtained for each patient, during each day until the fifth day after ictus.
Results: Mean arterial glucose concentrations during the first 5 days since ictus were positively correlated with mean PRx (Pearson correlation coefficient = 0.25, p = 0.02). The correlation was strongest on the first day after injury (Pearson correlation coefficient = 0.47, p = 0.008).
Conclusion: Our preliminary findings indicate that increased blood glucose may impair cerebrovascular reactivity, potentially contributing to a mechanistic link between increased blood glucose and poorer outcome after TBI.
Similar articles
-
Pressure autoregulation monitoring and cerebral perfusion pressure target recommendation in patients with severe traumatic brain injury based on minute-by-minute monitoring data.J Neurosurg. 2014 Jun;120(6):1451-7. doi: 10.3171/2014.3.JNS131500. Epub 2014 Apr 18. J Neurosurg. 2014. PMID: 24745709
-
'Long' pressure reactivity index (L-PRx) as a measure of autoregulation correlates with outcome in traumatic brain injury patients.Acta Neurochir (Wien). 2012 Sep;154(9):1575-81. doi: 10.1007/s00701-012-1423-0. Epub 2012 Jun 29. Acta Neurochir (Wien). 2012. PMID: 22743796
-
Novel index for predicting mortality during the first 24 hours after traumatic brain injury.J Neurosurg. 2018 Dec 21;131(6):1887-1895. doi: 10.3171/2018.7.JNS18995. Print 2019 Dec 1. J Neurosurg. 2018. PMID: 30579283
-
[How can we determine the best cerebral perfusion pressure in pediatric traumatic brain injury?].Ann Fr Anesth Reanim. 2013 Dec;32(12):e225-9. doi: 10.1016/j.annfar.2013.10.008. Epub 2013 Nov 5. Ann Fr Anesth Reanim. 2013. PMID: 24199905 Review. French.
-
Alternative continuous intracranial pressure-derived cerebrovascular reactivity metrics in traumatic brain injury: a scoping overview.Acta Neurochir (Wien). 2020 Jul;162(7):1647-1662. doi: 10.1007/s00701-020-04378-7. Epub 2020 May 8. Acta Neurochir (Wien). 2020. PMID: 32385635 Review.
Cited by
-
Regulation of the cerebral circulation: bedside assessment and clinical implications.Crit Care. 2016 May 5;20(1):129. doi: 10.1186/s13054-016-1293-6. Crit Care. 2016. PMID: 27145751 Free PMC article. Review.
-
Temporal profile of intracranial pressure and cerebrovascular reactivity in severe traumatic brain injury and association with fatal outcome: An observational study.PLoS Med. 2017 Jul 25;14(7):e1002353. doi: 10.1371/journal.pmed.1002353. eCollection 2017 Jul. PLoS Med. 2017. PMID: 28742817 Free PMC article.
-
High-physiological and supra-physiological 1,2-13C2 glucose focal supplementation to the traumatised human brain.J Cereb Blood Flow Metab. 2023 Oct;43(10):1685-1701. doi: 10.1177/0271678X231173584. Epub 2023 May 8. J Cereb Blood Flow Metab. 2023. PMID: 37157814 Free PMC article.
-
Impact of Arterial Carbon Dioxide and Oxygen Content on Cerebral Autoregulation Monitoring Among Children Supported by ECMO.Neurocrit Care. 2021 Oct;35(2):480-490. doi: 10.1007/s12028-021-01201-8. Epub 2021 Mar 9. Neurocrit Care. 2021. PMID: 33686559
-
Nutrition Therapy, Glucose Control, and Brain Metabolism in Traumatic Brain Injury: A Multimodal Monitoring Approach.Front Neurosci. 2020 Mar 24;14:190. doi: 10.3389/fnins.2020.00190. eCollection 2020. Front Neurosci. 2020. PMID: 32265626 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical