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Case Reports
. 2014 Jul 2;7(2):426-34.
doi: 10.1159/000365001. eCollection 2014 May.

A Report of Disseminated Carcinomatosis of the Bone Marrow Originating from Transverse Colon Cancer Successfully Treated with Chemotherapy Using XELOX plus Bevacizumab

Masayasu Naito  1 , Yoichiro Yoshida  1 , Naoya Aisu  1 , Shu Tanimura  1 , Seiichiro Hoshino  1 , Toshihiro Tanaka  2 , Satoshi Nimura  3 , Kazuo Tamura  2 , Yuichi Yamashita  1
Affiliations
Case Reports

A Report of Disseminated Carcinomatosis of the Bone Marrow Originating from Transverse Colon Cancer Successfully Treated with Chemotherapy Using XELOX plus Bevacizumab

Masayasu Naito et al. Case Rep Oncol. .

Abstract

A 61-year-old male, who had been admitted to another hospital due to disseminated intravascular coagulation (DIC), was referred to our hospital. Total colonoscopy, abdominal dynamic CT and positron-emission tomography revealed bone metastasis and multiple lymphocytic metastases from transverse colon cancer in addition to disseminated carcinomatosis of the bone marrow (DCBM). We immediately performed chemotherapy with XELOX + bevacizumab and denosumab against DCBM from transverse colon cancer in order to avoid radical surgery. In addition, we initiated the administration of recombinant human soluble thrombomodulin for 1 week to treat DIC. The patient was able to tolerate and receive 4 cycles of chemotherapy without any severe side effects. After receiving the 4 cycles of treatment, he recovered from DIC, and the bone and multiple lymphocytic metastases disappeared.

Keywords: Chemotherapy; Disseminated carcinomatosis of bone marrow; Disseminated intravascular coagulation; Transverse colon cancer.

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Figures

Fig. 1
Fig. 1
Complete stenosis of the transverse colon on TCS.
Fig. 2
Fig. 2
Intense stenosis with transverse colon cancer observed during an enema.
Fig. 3
Fig. 3
a–c. Multiple areas of metastatic lymph node invasion and bone metastasis on PET-CT.
Fig. 4
Fig. 4
Biopsy of bone marrow. Metastasis from a signet ring cell carcinoma (HE. ×400).
Fig. 5
Fig. 5
Stenosis of the transverse colon did not develop during the enema.
Fig. 6
Fig. 6
a–c. Multiple areas of metastatic lymph node invasion and bone metastasis on PET-CT.
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