Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Jan 1;5(1):19-25.

Stereotactic Ablative Radiotherapy (SABR): Impact on the Immune System and Potential for Future Therapeutic Modulation

Adam S Reese  1 , Steven J Feigenberg  1 , Azmat Husain  2 , Tonya J Webb  3 , Petr F Hausner  4 , Martin J Edelman  4 , Josephine Feliciano  4 , Katherine H Tkaczuk  4 , Navesh K Sharma  1
Affiliations

Stereotactic Ablative Radiotherapy (SABR): Impact on the Immune System and Potential for Future Therapeutic Modulation

Adam S Reese et al. Mol Cell Pharmacol. .

Abstract

Stereotactic ablative radiotherapy (SABR) has been demonstrated to provide excellent local control in several malignancies. Recent reports have suggested that this ablative dose may impact disease outside of the radiated area. Furthermore, these studies have implicated immune modulation as the primary mechanism of disease response outside the irradiated area. More specifically, T-cell stimulation and tumor necrosis factor-α modulation following high dose irradiation have been suggested as the responsible components of this phenomenon. In addition, the "abscopal effect" may play a role in disease response outside of the radiated area. We review the current literature regarding the effects of ablative radiation therapy, the potential for immune modulation from it, and the mechanisms of the distant effects it elicits.

Keywords: Ablative Radiotherapy; Immune Response; Therapeutic Modulation.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1. This is an example of GRID therapy for a patient with a large recurrent rectal cancer which delivers high doses of radiotherapy to portions of the tumor
This is in stark comparison to conventional radiation therapy which requires ensuring delivered dose to the entire tumor.
See this image and copyright information in PMC

References

    1. Chin LS, Regine WF, editors. Principles and pratice of sterotactic radiosurgery. 1st ed. New York: 2008.
    1. Ammar A. Lars Leksell’s vision-radiosurgery. Acta Neurochir Suppl. 1994;62:1–4. - PubMed
    1. Lunsford LD. Lars Leksell. Notes at the side of a raconteur. Stereotact Funct Neurosurg. 1996;67:153–168. - PubMed
    1. Andrews DW, Scott CB, Sperduto PW, et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet. 2004;363:1665–1672. - PubMed
    1. Timmerman R, Galvin J, Michalski J, Straube W, Ibbott G, Martin E, et al. Accreditation and quality assurance for Radiation Therapy Oncology Group: Multicenter clinical trials using Stereotactic Body Radiation Therapy in lung cancer. Acta Oncol. 2006;45:779–786. - PubMed

LinkOut - more resources