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Review
. 2014:2014:327950.
doi: 10.1155/2014/327950. Epub 2014 Jul 15.

Next generation delivery system for proteins and genes of therapeutic purpose: why and how?

Ashish Ranjan Sharma  1 , Shyamal Kumar Kundu  2 , Ju-Suk Nam  1 , Garima Sharma  1 , C George Priya Doss  3 , Sang-Soo Lee  1 , Chiranjib Chakraborty  4
Affiliations
Review

Next generation delivery system for proteins and genes of therapeutic purpose: why and how?

Ashish Ranjan Sharma et al. Biomed Res Int. 2014.

Abstract

Proteins and genes of therapeutic interests in conjunction with different delivery systems are growing towards new heights. "Next generation delivery systems" may provide more efficient platform for delivery of proteins and genes. In the present review, snapshots about the benefits of proteins or gene therapy, general procedures for therapeutic protein or gene delivery system, and different next generation delivery system such as liposome, PEGylation, HESylation, and nanoparticle based delivery have been depicted with their detailed explanation.

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Figures

Figure 1
Figure 1
Diagrammatic representation of lipid bilayer used for encapsulating therapeutic proteins and genes for their delivery.
Figure 2
Figure 2
Schematic diagram representing systemic delivery of therapeutic proteins or genes following conjugation with polyethylene glycol molecules. Here, structural formulae for linear PEG and branched mPEG are also displayed.
Figure 3
Figure 3
Schematic diagram depicting targeted delivery of antibody labelled silica nanoparticle to the tumour cell antigen.
See this image and copyright information in PMC

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