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. 2014;36(8):818-30.
doi: 10.1080/13803395.2014.943695. Epub 2014 Aug 15.

Executive function late effects in survivors of pediatric brain tumors and acute lymphoblastic leukemia

Amanda L Winter  1 , Heather M Conklin, Vida L Tyc, Heather Stancel, Pamela S Hinds, Melissa M Hudson, Lisa S Kahalley
Affiliations

Executive function late effects in survivors of pediatric brain tumors and acute lymphoblastic leukemia

Amanda L Winter et al. J Clin Exp Neuropsychol. 2014.

Abstract

Background: Survivors of pediatric brain tumors (BT) and acute lymphoblastic leukemia (ALL) are at risk for neurocognitive late effects related to executive function.

Procedure: Survivors of BT (48) and ALL (50) completed neurocognitive assessment. Executive function was compared to estimated IQ and population norms by diagnostic group.

Results: Both BT and ALL demonstrated relative executive function weaknesses. As a group, BT survivors demonstrated weaker executive functioning than expected for age. Those BT survivors with deficits exhibited a profile suggestive of global executive dysfunction, while affected ALL survivors tended to demonstrate specific rapid naming deficits.

Conclusion: Findings suggest that pediatric BT and ALL survivors may exhibit different profiles of executive function late effects, which may necessitate distinct intervention plans.

Keywords: Brain tumor; Executive function; Late effects; Leukemia; Pediatric.

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References

    1. Alvarez JA, Scully RE, Miller TL, Armstrong FD, Constine LS, Friedman DL, Lipshultz SE. Long-term effects of treatments for childhood cancers. Current Opinion in Pediatrics. 2007;19:23–31. - PubMed
    1. American Cancer Society Cancer facts & figures. 2013 Retrieved from http://www.cancer.org.
    1. Arnett AB, Pennington BF, Willcutt E, Dmitrieva J, Byrne B, Samuelsson S, Olson RK. A cross-lagged model of the development of ADHD inattention symptoms and rapid naming speed. Journal of Abnormal Child Psychology. 2012;40:1313–1326. - PMC - PubMed
    1. Armstrong FD. Cancer and blood disorders in childhood: Biopsychosocial-developmental issues in assessment and treatment. In: Brown RT, editor. Comprehensive handbook of childhood cancer and sickle cell disease: A biopsychosocial approach. Oxford University Press; New York, NY: 2006. pp. 17–32.
    1. Armstrong FD, Briery BG. Childhood cancer and the school. In: Brown RT, editor. Handbook of pediatric psychology in school settings. Erlbaum; Mahwah, NJ: 2004. pp. 263–281.

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