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. 2015 Feb;35(2):238-43.
doi: 10.1097/IAE.0000000000000326.

Obstructive sleep apnea and central serous chorioretinopathy

Frank L Brodie  1 , Emily S Charlson, Tomas S Aleman, Rebecca T Salvo, Dina Y Gewaily, Marisa K Lau, Neil D Farren, Stephanie B Engelhard, Maxwell Pistilli, Alexander J Brucker
Affiliations

Obstructive sleep apnea and central serous chorioretinopathy

Frank L Brodie et al. Retina. 2015 Feb.

Abstract

Purpose: The purpose of this study was to determine if there is an association between obstructive sleep apnea (OSA) and central serous chorioretinopathy (CSCR).

Methods: Patients with CSCR without a history of steroid use or secondary retinal disease were matched based on age/gender/body mass index with control patients and administered the Berlin Questionnaire to assess for OSA risk. Patients were scored "OSA+" if they were at "high risk" on the Berlin Questionnaire or reported a previous OSA diagnosis. Rates of OSA+ were compared between the 2 groups, odds ratio and its 95% confidence interval was calculated using exact conditional logistic regression.

Results: Forty-eight qualifying patients with CSCR were identified. There were no statistically significant differences between the CSCR and control groups by age (mean = 55 years), gender (79% male), body mass index (mean = 28.2), history of diabetes, or hypertension. Within the CSCR group, 22 patients (45.8%) were OSA+ versus 21 control patients (43.8%) (difference = 2.1%; 95% confidence interval, -18.2% to 22.2%; exact odds ratio = 1.08, 95% confidence interval, 0.47-2.49; P = 1.00).

Conclusion: When compared with matched controls, patients with CSCR did not have statistically significant higher rates of OSA risk or previous diagnosis. This finding contrasts with previous work showing a strong association between the diseases. The divergence is likely due to our matching controls for body mass index, a significant risk factor for OSA.

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Conflict of interest statement

None of the authors have any conflicting interests to disclose.

Figures

Fig. 1
Fig. 1
Description of the recruitment of patients with CSCR.
Fig. 2
Fig. 2
Patients with OSA+ (either “high risk” for OSA or previously diagnosed OSA).
See this image and copyright information in PMC

References

    1. Chin K, Hirai M, Kuriyama T, et al. Changes in the arterial PCO2 during a single night’s sleep in patients with obstructive sleep apnea. Intern Med. 1997;36:454–460. - PubMed
    1. Pack AI, Pien GW. Update on sleep and its disorders. Annu Rev Med. 2011;62:447–460. - PubMed
    1. Kasper DL, Fauci AS, Longo DL, et al., editors. Harrison’s Principles of Internal Medicine. 17. New York, NY: McGraw-Hill Medical; 2008. pp. 1665–1667.
    1. Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005;365:1046–1053. - PubMed
    1. Grover DP. Obstructive sleep apnea and ocular disorders. Curr Opin Ophthalmol. 2010;21:454–458. - PubMed

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