[Pulmonary hypertension: definition, diagnostic and new classification]
- PMID: 25127985
- DOI: 10.1016/j.lpm.2014.07.005
[Pulmonary hypertension: definition, diagnostic and new classification]
Abstract
Pulmonary hypertension (PH): mean pulmonary arterial pressure (mPAP) ≥ 25 mm Hg on right heart catheterization at rest. Pulmonary arterial hypertension (PAH): mPAP ≥ 25 mm Hg, pulmonary capillary wedge pressure (PCWP) ≤ 15 mm Hg and pulmonary vascular resistances (PVR) >3 Wood units. Patients with compatible symptoms (exertional dyspnea, syncopes, signes of right heart failure) can show signs of PH on cardiac echography and therefore need to be investigated in search of the cause of PH. After ruling out the frequent causes of PH (left heart and chronic respiratory diseases), the V/Q lung scan is used to screen for patients with post-embolic PH, that need to be further investigated hemodynamically and radiologically in order to decide operability. For the rest of the patients, only right heart catheterization can identify patients with precapillary PH and these patients must be further evaluated (clinically, by blood samples and by imaging techniques) in order to be classified in one the PH groups of the classification. For the future the discovery of novel risk factors and understanding the mechanism involved with the already known ones represent two major points of research.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.
Similar articles
-
[Diagnosis and classification of pulmonary hypertension].Presse Med. 2010 Jun;39 Suppl 1:1S3-15. doi: 10.1016/S0755-4982(10)70002-6. Presse Med. 2010. PMID: 20732615 French.
-
Definitions and diagnosis of pulmonary hypertension.J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D42-50. doi: 10.1016/j.jacc.2013.10.032. J Am Coll Cardiol. 2013. PMID: 24355641 Review.
-
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).Eur Heart J. 2016 Jan 1;37(1):67-119. doi: 10.1093/eurheartj/ehv317. Epub 2015 Aug 29. Eur Heart J. 2016. PMID: 26320113 No abstract available.
-
Pulmonary hypertension due to left heart diseases.J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D100-8. doi: 10.1016/j.jacc.2013.10.033. J Am Coll Cardiol. 2013. PMID: 24355634 Review.
-
Left heart abnormalities in connective tissue disease patients with pre-capillary pulmonary hypertension as well as borderline mean pulmonary arterial pressure.Mod Rheumatol. 2015 Sep;25(5):744-7. doi: 10.3109/14397595.2015.1005871. Epub 2015 Jun 12. Mod Rheumatol. 2015. PMID: 25736353
Cited by
-
Drug abuse and HIV-related pulmonary hypertension: double hit injury.AIDS. 2018 Nov 28;32(18):2651-2667. doi: 10.1097/QAD.0000000000002030. AIDS. 2018. PMID: 30234598 Free PMC article. Review.
-
Microarray analysis after umbilical cord blood derived mesenchymal stem cells injection in monocrotaline-induced pulmonary artery hypertension rats.Anat Cell Biol. 2014 Dec;47(4):217-26. doi: 10.5115/acb.2014.47.4.217. Epub 2014 Dec 23. Anat Cell Biol. 2014. PMID: 25548719 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials