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. 1989 Mar;61(1):31-6.

Bacterial chemistry-III: preliminary studies on trypanosomal activities of Chromobacterium violaceum products

N Durán  1 , V Campos, R Riveros, A Joyas, M F Pereira, M Haun
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  • PMID: 2512826

Bacterial chemistry-III: preliminary studies on trypanosomal activities of Chromobacterium violaceum products

N Durán et al. An Acad Bras Cienc. 1989 Mar.

Abstract

It has been found that the pigment-I from Chromobacterium violaceum, 3-[1,2-dihydro5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-yli diene] 1,3-dihydro-2H-indol-2-one, has trypanocide activity. The formylated derivatives, pigment-III, immobilized 100% of the Trypanosoma cruzi at a level of 46 microM after 48 h of interaction with a total growth inhibition in the same period. Pigment-I exhibited low toxicity and a DNA synthesis inhibition similar to that of Nifurtimox, a known trypanocide compound.

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