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. 2014 Aug;51(8):651-3.
doi: 10.1007/s13312-014-0470-4.

Clinical profile of scrub typhus in children and its association with hemophagocytic lymphohistiocytosis

Naveen Sankhyan  1 , L G Saptharishi, Kandasamy Sasidaran, Anil Kanga, Sunit C Singhi
Affiliations
Free article

Clinical profile of scrub typhus in children and its association with hemophagocytic lymphohistiocytosis

Naveen Sankhyan et al. Indian Pediatr. 2014 Aug.
Free article

Abstract

Objective: To study the clinical profile of children with scrub typhus and its association with hemophagocytic lymphohistiocytosis.

Methods: Children presenting with unexplained fever and multi-systemic involvement between May to December 2011 were tested for scrub typhus using IgM ELISA kits. Occurrence of Hemophagocytic lymphohistiocytosis in IgM positive cases of scrub typhus was studied.

Results: Of the 35 children with unexplained fever and multi-systemic involvement, 15 children (9 boys) tested positive for scrub typhus. Thrombocytopenia, hypoalbuminemia and raised hepatic transaminases were observed in all children. Out of seven children evaluated for hemophagocytic lymphohistiocytosis. 3 met the criteria for hemophagocytosis. Two children (one with hemophagocytic lymphohistiocytosis) died.

Conclusions: Scrub typhus is a common cause of unexplained fever in children in northern India. Hemophagocytic lymphohistiocytosis can occasionally complicate scrub typhus in children.

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