Stress and asthma: novel insights on genetic, epigenetic, and immunologic mechanisms

Abstract

In the United States the economically disadvantaged and some ethnic minorities are often exposed to chronic psychosocial stressors and disproportionately affected by asthma. Current evidence suggests a causal association between chronic psychosocial stress and asthma or asthma morbidity. Recent findings suggest potential mechanisms underlying this association, including changes in the methylation and expression of genes that regulate behavioral, autonomic, neuroendocrine, and immunologic responses to stress. There is also evidence suggesting the existence of susceptibility genes that predispose chronically stressed youth to both post-traumatic stress disorder and asthma. In this review we critically examine published evidence and suggest future directions for research in this field.

Keywords: Asthma; genetics; immune system; neuroendocrine system; psychosocial stress.

Figure 1

Potential causal mechanisms for stress-related asthma or asthma morbidity.