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. 2014 Aug 14;20(30):10262-78.
doi: 10.3748/wjg.v20.i30.10262.

Inflammatory bowel disease in pediatric and adolescent patients: a biomolecular and histopathological review

Luciana Rigoli  1 , Rosario Alberto Caruso  1
Affiliations

Inflammatory bowel disease in pediatric and adolescent patients: a biomolecular and histopathological review

Luciana Rigoli et al. World J Gastroenterol. .

Abstract

Crohn's disease (CD) and ulcerative colitis (UC) are the two main forms of inflammatory bowel disease (IBD) with both overlapping and distinct clinical, pathological and biomolecular features. It has been suggested that pediatric IBD is a distinct disease entity, with probably different disease subtypes.The aim of this study is to review and summarize the evolution of the current concept of pediatric IBD. The results of this review reinforce the idea that pediatric CD and UC may be further classified in various clinicopathologic entities. For clinicians and pathologists convenience, practical algorithms for the distinction of the various subphenotypes of pediatric IBD are also provided.

Keywords: Crohn’s disease; Histopathology; Molecular biology; Pediatric inflammatory bowel disease; Ulcerative disease.

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Figures

Figure 1
Figure 1
Distinct clinicopathological and biomolecular features of the pediatric colonic inflammatory bowel disease. IBD: Inflammatory bowel disease; CD: Crohn’s disease; UC: Ulcerative colitis.
Figure 2
Figure 2
Subtypes of Crohn’s disease. CD: Crohn’s disease.
See this image and copyright information in PMC

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