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. 2014 Jul 11:8:17-22.
doi: 10.2174/1874104501408010017. eCollection 2014.

Basic aspects of the pharmacodynamics of tolperisone, a widely applicable centrally acting muscle relaxant

Kornelia Tekes  1
Affiliations

Basic aspects of the pharmacodynamics of tolperisone, a widely applicable centrally acting muscle relaxant

Kornelia Tekes. Open Med Chem J. .

Abstract

Tolperisone (2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one hydro-chloride) was introduced in the clinical practice more than forty years ago and is still evaluated as a widely applicable compound in pathologically elevated skeletal muscle tone (spasticity) and related pains of different origin. In the present review, basic pharmacodynamic effects measured on whole animals, analyses of its actions on cell and tissue preparations and molecular mechanism of action on sodium and calcium channels are summarized as recently significantly new data were reported.

Keywords: Centrally acting muscle relaxant; N-type calcium channel blocking; Tolperisone.; inhibition of monosynaptic reflexes; sodium channels; spasticity.

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Figures

Fig. (1)
Fig. (1)
Chemical structure of tolperisone.
Fig. (2)
Fig. (2)
Mechanism of action of Tolperisone. (Abbreviations: DR: Dorsal root, DRG: Dorsal root ganglion, VR: Ventral root, SN: Spinal nerve, DR-VRP: Dorsal root stimulation-evoked ventral root potential).
See this image and copyright information in PMC

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