Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature

Abstract

Ulcerative colitis (UC) is one of the main types of inflammatory bowel disease, which is caused by dysregulated immune responses in genetically predisposed individuals. Several genetic factors, including interleukin and interleukin receptor gene polymorphisms and other inflammation-related genes play central role in mediating and modulating the inflammation in the human body, thereby these can be the main cause of development of the disease. It is clear these data are very important for understanding the base of the disease, especially in terms of clinical utility and validity, but summarized literature is exiguous for challenge health specialist that can used in the clinical practice nowadays. This review summarizes the current literature on inflammation-related genetic polymorphisms which are associated with UC. We performed an electronic search of Pubmed Database among publications of the last 10 years, using the following medical subject heading terms: UC, ulcerative colitis, inflammation, genes, polymorphisms, and susceptibility.

Keywords: Genes; Inflammatory factors; Polymorphisms; Susceptibility; Ulcerative colitis.

Figure 1

The Ulcerative colitis-associated risk loci. Damage of the epithelial barrier (E), the mucinous biofilm layer secreted from goblet cells (G), the antibacterial peptides (e.g., defensines) produced by Paneth cells (P) and the tight junctions leads to increased permeability in ulcerative colitis (UC). Antigen presenting cells (APCs) (i.e., macrophages and dendritic cells) in the lamina propria are increased in absolute number in UC, they bind microbial products through detection molecules of the innate immune system, including Toll like receptors (TLRs) on the cell surface and on the cytoplasmatic NOD-like receptors (NLRs). Stimulation of these receptors induces intracellular signaling cascades, resulting in secretion of large number of cytokines, chemokines, and immunomodulatory factors. The development of the Th2, Th17 and Treg subsets from naïve, Th0 cells during primary immune response is mainly determined by cytokines and chemokines, and is under the control of certain transcription factors: T-bet (T-box expressed in T cells), GATA3 (GATA binding protein), RORγt (retinoid-related orphan receptor γt), RORα, STATs (signal transducer and activator of transcription) and FoxP3 (forkhead box P3). Leukocyte migration and recruitment from vessels is mediated by selectins, integrins, ICAMs and chemokines (i.e., c-c motif chemokine ligand, CXCL). The UC-associated loci encode genes involved in: (1) maintenance of epithelial barrier integrity (e.g., ECM1, CDH1, HNF4A, LAMB1, PTGER4, SLC22A4/SLC22A5, MYO9B, MDR1); (2) antigen pattern recognition (e.g., NLRs, TLRs); (3) innate and adaptive immunological responses (e.g., IL-23R, IL-12B, TNFα, IL10R, JAK2, STAT3, HLA-region); and (4) leukocyte recruitment (integrin α4β7, ICAM-1, MAdCAM-1, CXCLs, CCRs).