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Review
. 2014 Aug 6;5(3):122-38.
doi: 10.4292/wjgpt.v5.i3.122.

Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia

John M Rosen  1 , Jose T Cocjin  1 , Jennifer V Schurman  1 , Jennifer M Colombo  1 , Craig A Friesen  1
Affiliations
Review

Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia

John M Rosen et al. World J Gastrointest Pharmacol Ther. .

Abstract

Functional gastrointestinal disorders (FGID) are common clinical syndromes diagnosed in the absence of biochemical, structural, or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age, geography, and culture. Etiology of abdominal pain associated FGIDs, including functional dyspepsia (FD), remains incompletely understood, but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD, with focus on pediatric data when available, and provides a summary of potential therapeutic targets.

Keywords: Functional dyspepsia; Motility; Visceral hypersensitivity.

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Figures

Figure 1
Figure 1
Overview of electromechanical disturbances in functional dyspepsia.
See this image and copyright information in PMC

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